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2023
36. A machine learning tool to predict substrate-adaptive conditions for Pd-catalyzed C-N couplings
N. Ian Rinehart, Rakesh K. Saunthwal, Joël Wellauer, Andrew F. Zahrt, Lukas Schlemper, Alexander S. Shved, Raphael Bigler, Serena Fantasia, Scott E. Denmark
Science 2023 381, 965–972 (DOI: 10.1126/science.adg2114)
35. Enantioselective intramolecular α-arylation of benzylamine derivatives: synthesis of a precursor to levocetirizine
Rakesh K. Saunthwal, Maria Schwarz, Rajendra K. Mallick, William Terry-Wright, Jonathan Clayden
Angew. Chem. Int. Ed. 2023, e202216758 (https://doi.org/10.1002/anie.202216758)
2022
34. Expedient Access to Polyaromatic Biaryls by Unconventional Ag-Catalyzed Cycloaromatization of Alkynylthiophenes and Au-Catalyzed Double C−H Activation
Rakesh K. Saunthwal, Kapil Mohan Saini, Nicolas Grimblat, Abhinandan K. Danodia, Sushil Kumar, Vincent Gandon and Akhilesh K. Verma,
Org. Lett. 2022, 24, 5018–5022 (https://doi.org/10.1021/acs.orglett.2c01665)
33. C(sp3)-Arylation by Conformationally Accelerated Intramolecular Nucleophilic Aromatic Substitution (SNAr)
Steven M. Wales, § Rakesh K. Saunthwal, § and Jonathan Clayden,
Acc. Chem. Res. 2022. 55, 1731-1747 (§ These authors contributed equally to this work) Most Read article
(https://doi.org/10.1021/acs.accounts.2c00184)
32. Enantioselective one-carbon ring expansion of aromatic rings by simultaneous formation and chromoselective irradiation of a transient coloured enolate"
Rakesh. K. Saunthwal, James Mortimer, Andrew Orr-Ewing and Jonathan Clayden
Chem. Sci., 2022, 13, 2079. (https://doi.org/10.1039/D1SC06684F)
2021
31. Tandem 6π-Azatriene Electrocyclization of Fused Amino-Cyclopentenones: Synthesis of Functionalized Pyrrolo- and Indolo-quinoxaline"
Kapil Mohan Saini, Rakesh K. Saunthwal, Ankit Kumar and Akhilesh K. Verma
Org. Lett. 2021, 23, 7586-7591. (https://doi.org/10.1021/acs.orglett.1c02782)
2020
30. Synthesis of Cyclopentaquinolinone and Cyclopentapyridinone from ortho-alkynyl-N-arylaldehyde via Superbase-promoted C-N, C-O and C-C Bonds Formation”
Kapil Mohan Saini, Rakesh K. Saunthwal, Sushmita and Akhilesh K. Verma
Org. Biomol. Chem., 2020, 18, 5594-5601. (https://doi.org/10.1039/D0OB01281E)
29. Transition-Metal-Free Reverse Reactivity of (2-alkynyl)-Arylaldimines: Assembly of Functionalized Amino-Indinones
Kapil Mohan Saini, Rakesh K. Saunthwal, Sushmita, and Akhilesh K. Verma
Chem. Eur. J. 2020, 26, 1017–1021, Hot Paper (https://doi.org/10.1002/chem.201904294)
2019
28. Dual Function of Cabon Tetrachloride: Synthesis of Chlorinated Heterocycles
Shiv Kumar,‡ Rakesh K Saunthwal,‡ Kapil Mohan Saini and Akhilesh K. Verma
Chem. Commun., 2019, 55, 10721-10724
(‡These authors contributed equally to this work.) (https://doi.org/10.1039/C9CC04746H)
27. Connective Synthesis of 5,5-Disubstituted Hydantoins by Tandem α-Amination and α-Arylation of Silyl Ketene Acetals
Rakesh K. Saunthwal, Matthew Cornall, Roman Abrams, John Ward and Jonathan Clayden
Chem. Sci. 2019, 10, 3408-3412 (https://doi.org/10.1039/C8SC05263H)
“Synthesis of 5,5-Disubstituted Hydantoins” Synfacts 2019, 15(07), 0729
26. On Water: Iodine-Mediated Direct Construction of 1, 3-Benzothiazines from
ortho-Alkynylanilines by Regioselective 6-Exo-dig Cyclization
Kapil Mohan Saini, Rakesh K. Saunthwal, Shiv Kumar, and Akhilesh K. Verma
Org. Biomol. Chem. 2019, 17, 2657-2662 (https://doi.org/10.1039/C9OB00128J)
25. On Water: Metal-free Synthesis of Highly Functionalized Benzothiazolylidene from
ortho-Haloanilines
Kapil Mohan Saini, Rakesh K. Saunthwal, Shiv Kumar, and Akhilesh K. Verma.
J. Org. Chem. 2019, 84 (5), 2689–26987 (https://doi.org/10.1021/acs.joc.8b03107)
2018
24. Base-Mediated Deuteration of Organic Molecules: A Mechanistic Insight
Monika Patel, Rakesh K. Saunthwal, Akhilesh K. Verma
ACS Omega, 2018, 3, 10612– 10623 (https://doi.org/10.1021/acsomega.8b01329)
2017
23. Pd-Catalyzed One-Pot Sequential Cross-Coupling Reactions of Tetrabromothiophene
Kapil Mohan Saini‡ Rakesh K. Saunthwal ‡ and Akhilesh K. Verma,
Org. Biomol. Chem., 2017, 15, 10289-10298 (‡These authors contributed equally to this work)
(https://doi.org/10.1039/C7OB02601C)
22. Chemoselective Oxidative Esterification and Iodocyclization of Hydroxyalkynyl Aldehydes
Shiv Kumar,Monika Patel,Rakesh K. Saunthwal and Akhilesh K. Verma
Asian J. Org. Chem. 2017, 5, 1893–1902 (https://doi.org/10.1002/ajoc.201700375)
21. Ag(I)-Catalyzed Cycloisomerization Reactions: Synthesis of Substituted Phenanthrenes and Naphthothiophenes
Rakesh K. Saunthwal, Abhinandan K. Danodia, Kapil Mohan Sainiand Akhilesh K. Verma
Org. Biomol. Chem. 2017, 15, 6934-6942 (https://doi.org/10.1039/C7OB01646H)
20. TFA-Mediated One-Pot Synthesis of Furo-Fused Quinoxalines/ Pyrazines
Kapil Mohan Saini, Sonu Kumar, Monika Patel, Rakesh K. Saunthwal and Akhilesh K. Verma,
Eur. J. Org. Chem. 2017, 3707–3715 (https://doi.org/10.1002/ejoc.201700541)
19. Base-Mediated Hydroamination of Alkynes”
Monika Patel, Rakesh K. Saunthwal, and Akhilesh K. Verma,
Acc. Chem. Res 2017, 50, 240–254 (https://doi.org/10.1021/acs.accounts.6b00449)
18. Regioselective Preferential C-H Activation of α, β-Sterically Hindered 1,3-Dienes over [4+2] cycloaddition
Rakesh K. Saunthwal, Kapil Mohan Saini, Monika Patel and Akhilesh K. Verma
Tetrahedron. 2017, 73, 2415-2431 (https://doi.org/10.1016/j.tet.2017.03.028)
2016
17. Metal and Protection-Free [4+2] Cycloadditions of Alkynes with Azadienes: An Efficient Assembly of Functionalized Quinolines”
Rakesh K. Saunthwal, Monika Patel and Akhilesh K. Verma
Org. Lett. 2016, 18, 2200–2203 (https://doi.org/10.1021/acs.orglett.6b00817)
“Metal- and Protection-free [4+2] Cycloadditions of Alkynes with Azadienes of Functionalized Quinolines” Highlighted in Org. Process Res. Dev. 2016, 20, 1691
16. Regioselective 5-endo-dig Electrophilic Iodocyclization of Enediynes: A Convenient Route to Iodo-substituted Indenes”
Rakesh K. Saunthwal, Abhinandan K. Dahanodia, Monika Patel and Akhilesh K. Verma
Chem. Asian J., 2016, 11, 3001–3007 (https://doi.org/10.1002/asia.201601085)
15. Regioselective Synthesis of C-3 Functionalized Quinolines via Hetero Diels-Alder Cycloaddition of Azadienes with Terminal Alkynes
Rakesh K. Saunthwal, Monika Patel and Akhilesh K. Verma
J. Org. Chem., 2016, 81, 6563–6572; (https://doi.org/10.1021/acs.joc.6b01186)
Highlighted in Organic Reaction Portal
14. Pd-catalyzed One-Pot Sequential Unsymmetrical Cross-Coupling Reactions of Aryl/Heteroaryl 1,2-Dihalides
Abhinandan K. Danodia, ‡ Rakesh K. Saunthwal‡ Monika Patel, Rakesh K. Tiwari and Akhilesh K. Verma
Org. Biomol. Chem. 2016, 14, 6487-6496 (‡These authors contributed equally to this work.) (https://doi.org/10.1039/C6OB01049K)
13. Palladium-catalyzed Intramolecular Fujiwara-Hydroarylation: Synthesis of Benzo[a]phenazines Derivatives
Sonu Kumar, Rakesh K. Saunthwal and Akhilesh K Verma,
J. Org. Chem., 2016, 81, 9912–9923 (https://doi.org/10.1021/acs.joc.6b02096)
12. Palladium Meets Copper: One-Pot Tandem Synthesis of Pyrido Fused Heterocycle via Sonogashira conjoined Electrophilic Cyclization
Sonu Kumar, Rakesh K. Saunthwal, Trapti Aggarwal and Akhilesh K. Verma
Org. Biomol. Chem. 2016, 14, 9063-9071; (https://doi.org/10.1039/C6OB01539E)
“When Palladium Meets Copper” SYNFACTS 2016, 12, 1255
11. Metal-Free Intermolecular Hydro-phenoxylation of Aryl Alkynes
Monika Patel, Rakesh K.Saunthwal, Devendra K. Dhaked and Prasad V. Bharatam, Akhilesh Kumar Verma
Asian J. Org. Chem. 2016, 4, 213–221. (https://doi.org/10.1002/ajoc.201500479)
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2015
10. Pd(II)-Catalyzed C-H Activation of Styrylindoles: Short, Efficient, and Regioselective Synthesis of Functionalized Carbazoles
Rakesh K. Saunthwal, Monika Patel, Sonu Kumar, Abhinandan K. Danodia, and Akhilesh K. Verma,
Chem. Eur. J. 2015, 21, 18601 – 18605. (https://doi.org/10.1002/chem.201503657) Hot article
9. Palladium-Catalyzed Triple Successive C−H Functionalization: Direct Synthesis of Functionalized Carbazoles from Indoles
Akhilesh K. Verma, Abhinandan K. Danodia, Rakesh K. Saunthwal, Monika Patel, and Deepak Choudhary
Org. Lett. 2015, 17, 3658–3661, Most read article (https://doi.org/10.1021/acs.orglett.5b01476)
8. On Water: Catalyst−free Chemoselective Synthesis of Highly Functionalized Tetrahydroquinazolines from 2-Aminophenylacrylate
Rakesh K. Saunthwal, Monika Patel, Sushil Kumar and Akhilesh K. Verma
Green Chem. 2015, 17, 1434-1441 (10.1039/C4GC02154A )
7. Pd-catalyzed Heck-conjoined Amidation and Concomitant Chemoselective Michael-addition: An Efficient Tandem Approach to Highly Functionalized Tetrahydroquinazolines from o-Haloanilines
Rakesh K. Saunthawal, Monika Patel, Abhinandan K. Danodia, Akhilesh K. Verma
Org. Biomol. Chem., 2015, 13, 1521-1530. (https://doi.org/10.1039/C4OB02286F)
6. Cu(II)-Catalyzed Tandem Synthesis of 2-Imino[1,3]benzothiazines from 2-Aminoaryl acrylates via Thioamidation and Concomitant Chemoselective thia-Michael Addition
Rakesh K. Saunthwal, Monika Patel, Sushil Kumar and Akhilesh K. Verma
Tetrahedron Lett., 2015, 56, 677-681 (https://doi.org/10.1016/j.tetlet.2014.12.058)
5. Nu-Addition vs SNAr study: Chemo-, Regio- and Stereoselective Preferential Hydrothiolation of Haloarylalkynes over S-arylation of aryl halides
Monika Patel, Rakesh K. Saunthwal and Akhilesh K. Verma
Asian J. Org. Chem. 2015, 4, 894 –898 (https://doi.org/10.1002/ajoc.201500239)
4. Tandem Approach to Benzothieno- and Benzofuropyridines from o-Alkynyl Aldehydes via Silver-Catalyzed6-endo-dig Ring Closure
Sonu Kumar, Carlos Cruz-Hernández, shilpi Pal, Rakesh K. Saunthwal, Monika Patel, Rakesh K. Tiwari, Eusebio Juaristi, and Akhilesh K. Verma
J. Org. Chem., 2015, 80, 10548–10560. (https://doi.org/10.1021/acs.joc.5b01647)
Silver-Catalyzed Heteroannulation Route to Benzofuro- and Benzothienopyridines” SYNFACTS 2016, 12, 0024
2014
3. Stereoselective tandem synthesis of thiazolo fused naphthyridines and thienopyridines from o-alkynyl-aldehydes via Au(III)-catalyzed regioselective 6-endo-dig ring closure”
Rajeev R. Jha, Rakesh K. Saunthwal and Akhilesh K. Verma
Org. Biomol. Chem., 2014, 12, 552-556 (10.1039/C3OB42035C )
2. Base-Catalyzed Stereoselective Intermolecular Addition of Imidazoles onto Alkynes: An Easy Access to Imidazolyl Enamines”
Monika Patel, Rakesh K. Saunthwal, Akhilesh K. Verma
Tetrahedron Lett., 2014, 55, 1310−1315 (https://doi.org/10.1016/j.tetlet.2013.12.100)
2013
1. On Water: Silver-Catalyzed Domino Approach for the Synthesis of Benzoxazine/Oxazine-Fused Isoquinolines and Naphthyridines from o-Alkynyl Aldehydes
Akhilesh K. Verma, Deepak Choudhary, Rakesh K. Saunthwal, Vineeta Rustagi, Monika Patel and Rakesh K. TiwariJ. Org. Chem., 2013, 78, 6657−6669 (https://doi.org/10.1021/jo4009639)
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